Total Vitamin D Intake and Risks of Early-Onset Colorectal Cancer and Precursors.

Abstract

BACKGROUND & AIMS:

Vitamin D has been implicated in colorectal cancer (CRC) pathogenesis, but it remains unknown whether total vitamin D intake is associated with early-onset CRC and precursors diagnosed before age 50.

METHODS:

We prospectively examined the association between total vitamin D intake and risks of early-onset CRC and precursors among women enrolled in the Nurses' Health Study II. Multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for early-onset CRC were estimated with Cox proportional hazards model. Multivariable-adjusted odds ratios (ORs) and 95% CIs for early-onset conventional adenoma and serrated polyp were estimated with logistic regression model.

RESULTS:

We documented 111 incident cases of early-onset CRC during 1,250,560 person-years of follow-up (1991 to 2015). Higher total vitamin D intake was significantly associated with a reduced risk of early-onset CRC (HR for ≥450 IU/day vs <300 IU/day, 0.49; 95% CI, 0.26-0.93; P for trend = .01). The HR per 400 IU/day increase was 0.46 (95% CI, 0.26-0.83). The inverse association was significant and appeared more evident for dietary sources of vitamin D (HR per 400 IU/day increase, 0.34; 95% CI, 0.15-0.79) than supplemental vitamin D (HR per 400 IU/day increase, 0.77; 95% CI, 0.37-1.62). For CRC precursors, the ORs per 400 IU/day increase were 0.76 (95% CI, 0.65-0.88) for conventional adenoma (n = 1,439) and 0.85 (95% CI, 0.75-0.97) for serrated polyp (n = 1,878).

CONCLUSIONS:

In a cohort of younger women, higher total vitamin D intake was associated with decreased risks of early-onset CRC and precursors.

• Authors: Hanseul Kim, Marla Lipsyc-Sharf, Xiaoyu Zong, Xiaoyan Wang, Jinhee Hur, Mingyang Song, Molin Wang, Stephanie A Smith-Warner, Charles Fuchs, Shuji Ogino, Kana Wu, Andrew T Chan, Yin Cao, Kimmie Ng, Edward L Giovannucci
• Journal: Gastroenterology (Gastroenterology) Vol. 161 Issue 4 Pg. 1208-1217.e9 (10 2021) ISSN: 1528-0012 [Electronic] United States
• PMID: 34245763 (Publication Type: Journal Article, Observational Study, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2021 AGA Institute. Published by Elsevier Inc. All rights reserved.

Chemical References

• Vitamins
• Vitamin D

Topics

• Adenoma (diagnosis, epidemiology, prevention & control)
• Adult
• Age of Onset
• Colonic Polyps (diagnosis, epidemiology, prevention & control)
• Colorectal Neoplasms (diagnosis, epidemiology, prevention & control)
• Female
• Humans
• Incidence
• Middle Aged
• Nurses
• Precancerous Conditions (diagnosis, epidemiology, prevention & control)
• Prospective Studies
• Protective Factors
• Risk Assessment
• Risk Factors
• Sex Factors
• Time Factors
• United States (epidemiology)
• Vitamin D (administration & dosage)
• Vitamins (administration & dosage)