Abstract | OBJECTIVE: To prospectively assess the efficacy of a biodegradable collagen matrix ( ologen) in dogs with uncontrolled glaucoma receiving an Ahmed glaucoma valve (AGV) implant. ANIMAL STUDIED: Five client-owned dogs with glaucoma (five eyes). PROCEDURES: Five eyes treated for uncontrolled glaucoma underwent AGV implantation with ologen. Ologen was placed on the AGV plate and tube with a scleral flap. Complete ophthalmological examinations were performed preoperatively and at 1 and 3 days, 1 and 2 weeks, and 1, 2, 3, and 6 months postoperatively. Surgical outcomes were assessed based on the intraocular pressure (IOP), vision, frequency of anti- glaucoma eye drops, and bleb morphology; complications, if any, were recorded. The number of dogs with an IOP <20 mmHg with or without topical medications were tabulated and compared to those with an IOP ≥20 mmHg or those requiring surgery to maintain the IOP at <20 mmHg. RESULTS: The IOP significantly decreased from 47.00 ± 5.09 mmHg preoperatively to 17.00 ± 0.71 mmHg 6 months postoperatively (p = .008). IOP was controlled (<20 mmHg) in 5/5 dogs at 6 months postoperatively. Brief periods of elevated IOP (IOP ≥ 20 mmHg, IOP spike) occurred in one eye (case 5) at 1 month (35 mmHg) and 2 months (33 mmHg) postoperatively. The anti- glaucoma eye drop frequency decreased from 3.2 ± 0.44 preoperatively to 1.6 ± 0.90 at 6 months postoperatively (p = .007). CONCLUSIONS: To our knowledge, this is the first study to assess the potential safety of AGV implantation with ologen for canine glaucoma. This method effectively controlled the IOP, without any adverse effects.
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Authors | Won-Gyun Hong, Joon-Young Kim, Suk-Jun Lee, Soon-Wuk Jeong |
Journal | Veterinary ophthalmology
(Vet Ophthalmol)
Vol. 24
Issue 4
Pg. 391-399
(Jul 2021)
ISSN: 1463-5224 [Electronic] England |
PMID | 34240540
(Publication Type: Clinical Trial, Veterinary, Journal Article)
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Copyright | © 2021 American College of Veterinary Ophthalmologists. |
Chemical References |
- Glycosaminoglycans
- collagen-glycosaminoglycan copolymer
- Collagen
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Topics |
- Animals
- Collagen
(adverse effects, therapeutic use)
- Dog Diseases
(drug therapy, surgery)
- Dogs
- Female
- Glaucoma
(surgery, veterinary)
- Glaucoma Drainage Implants
(veterinary)
- Glycosaminoglycans
(adverse effects, therapeutic use)
- Intraocular Pressure
(drug effects)
- Male
- Prospective Studies
- Treatment Outcome
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