Sexually transmitted infections among HIV serodiscordant partners: A secondary analysis of HIV Prevention Trial Network 052.

Abstract

Sexually transmitted infections (STIs) remain a public health concern because of their interaction(s) with HIV. In the HPTN 052 study, STIs were evaluated in both HIV-positive index cases and their HIV-negative partners at enrollment and at yearly follow-up visits. Our definition for STI was based on any infection with Chlamydia trachomatis, Neisseria gonorrhoeae, syphilis, or Trichomonas vaginalis. We used log-binomial regression models to identify factors associated with prevalent STIs. Generalized estimating equation models with the Poisson distribution were used to compare STI incidence between HIV-positive index cases and HIV-negative partners. 8.1% of the participants had STIs at enrollment. The prevalence of STIs (8.9 vs. 7.2) was higher in HIV-positive index cases than HIV-negative partners. Being female (prevalence ratio (PR) = 1.61; 95% CI: 1.20-2.16) or unmarried (PR = 1.92; 95% CI: 1.17-3.14) was associated with prevalent STIs. Compared to HIV-negative male partners, HIV-positive female index cases had a higher risk of STI acquisition (incidence rate ratio (IRR) = 2.25; 95% CI: 1.70-2.97). While we are implementing HIV prevention interventions for HIV-negative people, we should also intensify targeted STI prevention interventions, especially among HIV-positive women.

• Authors: Maganizo B Chagomerana, Mina C Hosseinipour, Jose Henrique Pilotto, Sharlaa Badal-Faesen, Mulinda Nyirenda, Emily Shava, Sheela V Godbole, Victor Akelo, Suwat Chariyalertsak, Ravindre Panchia, Myron Cohen
• Journal: International journal of STD & AIDS (Int J STD AIDS) Vol. 32 Issue 13 Pg. 1204-1211 (11 2021) ISSN: 1758-1052 [Electronic] England
• PMID: 34233535 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Topics

• Chlamydia Infections
• Chlamydia trachomatis
• Female
• Gonorrhea (epidemiology, prevention & control)
• HIV Infections (epidemiology, prevention & control)
• Humans
• Male
• Neisseria gonorrhoeae
• Prevalence
• Sexually Transmitted Diseases (epidemiology, prevention & control)