Novel semiconducting nano-agents incorporating tirapazamine for imaging guided synergistic cancer hypoxia activated photo-chemotherapy.

Abstract

For cancer treatment, the traditional monotherapy has the problems of low drug utilization rate, poor efficacy and easy recurrence of the cancer. Herein, nanoparticles (NPs) based on a novel semiconducting molecule (ITTC) are developed with excellent photostability, high photothermal conversion efficiency and good 1O2 generation ability. The chemotherapy of the hypoxia-activated prodrug tirapazamine (TPZ) was improved accordingly after oxygen consumption by the photodynamic therapy of ITTC NPs. Additionally, the metabolic process of ITTC NPs in vivo could be monitored in real time for fluorescence imaging guided phototherapy, which presented great passive targeting ability to the tumor site. Remarkably, both in vitro and in vivo experiments demonstrated that the combination of ITTC NPs and TPZ presented excellent synergistic tumor ablation through photothermal therapy, photodynamic therapy and hypoxia-activated chemotherapy with great potential for clinical applications in the future.

• Authors: Guorong Zhang, Weixiang Wang, Huihui Zou, Zheng Wei, Chuanhui Song, Jianchuan Ran, Zichen Cao, Yu Cai, Wei Han
• Journal: Journal of materials chemistry. B (J Mater Chem B) Vol. 9 Issue 26 Pg. 5318-5328 (07 07 2021) ISSN: 2050-7518 [Electronic] England
• PMID: 34231629 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Photosensitizing Agents
• Tirapazamine

Topics

• Animals
• Antineoplastic Agents (administration & dosage, chemistry, pharmacology)
• Cell Line, Tumor
• Cell Survival (drug effects)
• Drug Screening Assays, Antitumor
• Humans
• Hypoxia (diagnostic imaging, drug therapy)
• Injections, Intraperitoneal
• Male
• Mice
• Mice, Inbred BALB C
• Mice, Nude
• Molecular Structure
• Nanoparticles (administration & dosage, chemistry)
• Neoplasms, Experimental (diagnostic imaging, drug therapy)
• Optical Imaging
• Photosensitizing Agents (administration & dosage, chemistry, pharmacology)
• Semiconductors
• Tirapazamine (administration & dosage, chemistry, pharmacology)