The Prognostic Significance of Plakophilin-1 Expression in Esophageal Cancer.

Abstract

BACKGROUND/AIM:

Plakophilin 1 (PKP1) expression is inversely related to cancer grade. This study aimed to evaluate whether PKP1 is a prognostic marker for esophageal cancer (EC).

MATERIALS AND METHODS:

We tested immunohistochemically for PKP1 in squamous cell carcinoma EC specimens from 99 patients, including cytoplasmic (C), membrane (M), and nuclear (N) cellular areas, and analyzed their relationships with clinicopathological factors.

RESULTS:

PKP1stains were stratified into strong and weak for all three cellular areas. Staining was inversely related to tumor depth (C: p=0.002, M: p=0.00007, N: p=0.02), lymph node metastasis (C: p=0.003, M: p=0.001, N: p=0.004) and pathological stage (C: p=0.0004, M: p=0.0001, N: p=0.006). Cytoplasmic and membrane staining were inversely related to vessel invasion. Patients with strong C stain had a better overall survival than those with weak C stains (p=0.01). Disease-free survival of patients with strong M stains was better than that of those with weak staining (p=0.01).

CONCLUSION:

Cytoplasmic and membrane PKP1 expression is a possible prognostic marker for EC.

• Authors: Junki Fujita, Masanobu Nakajima, Hiroto Muroi, Maiko Kikuchi, Keisuke Ihara, Takeshi Yamaguchi, Masatoshi Nakagawa, Shinji Morita, Takatoshi Nakamura, Takashi Tsuchioka, Kazuyuki Kojima
• Journal: Anticancer research (Anticancer Res) Vol. 41 Issue 7 Pg. 3401-3407 (Jul 2021) ISSN: 1791-7530 [Electronic] Greece
• PMID: 34230135 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• PKP1 protein, human
• Plakophilins

Topics

• Aged
• Cell Nucleus (metabolism, pathology)
• Cytoplasm (metabolism, pathology)
• Disease-Free Survival
• Esophageal Neoplasms (metabolism, pathology)
• Esophageal Squamous Cell Carcinoma (metabolism, pathology)
• Female
• Gene Expression Regulation, Neoplastic (physiology)
• Humans
• Lymphatic Metastasis (pathology)
• Male
• Plakophilins (metabolism)
• Prognosis