Blood-derived integration-free induced pluripotent stem cells (iPSCs) from one 53-years-old male donor with APOE-ε4/ε4 genotype.

Abstract

Apolipoprotein E ε4 allele (APOE4) is a minor allele of the APOE gene associated with a higher risk for Alzheimer's Disease (AD) and Vascular Dementia (VD). While lipid deposition and chronic inflammation in glia are the commonalities between atherosclerosis, VD, and AD. Hence, we presented an iPSC line of an AD male donor suffering from Cerebrovascular Atherosclerosis with APOE-ε4/ε4 alleles background. Furthermore, we differentiated the iPSCs into astrocyte to explore pathogenesis in APOE4 related dementia. The characterized iPSC line expressed typical pluripotency markers and showed differentiation potential and normal karyotype.

• Authors: Xiaowei Ma, Jun Ma, Ruiyun Guo, Juan Du, Baofeng Feng, Xin Liu, Xiaofeng Du, Zhenhuan Ma, Huixian Cui
• Journal: Stem cell research (Stem Cell Res) Vol. 54 Pg. 102450 (07 2021) ISSN: 1876-7753 [Electronic] England
• PMID: 34218115 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Chemical References

• Apolipoprotein E4

Topics

• Alleles
• Alzheimer Disease (genetics)
• Apolipoprotein E4 (genetics)
• Genotype
• Humans
• Induced Pluripotent Stem Cells
• Male