The metabolic role of spermidine in obesity: Evidence from cells to community.

Abstract

Spermidine is a natural polyamine existing in all living cells known to play an important role in cellular functions. Recently, several studies have reported the effect of alterations in the spermidine pool on metabolic pathways. It has been shown that activation of spermidine/spermine N-1-acetyl-transferase (SSAT), the rate-limiting enzyme in polyamine catabolism, improved glucose and lipid metabolism. In addition, spermidine supplementation has been shown to protect against diet-induced obesity in animal models. However, some clinical studies demonstrated that polyamine levels are increased in childhood obesity and metabolic syndrome patients with type 2 diabetes (T2DM), while polyamine-rich food is associated with a lower incidence of cardiovascular disease (CVD). Therefore, this review aims to summarize and discuss the evidence from in vitro, in vivo and clinical studies on the possible roles of spermidine on metabolic pathways under physiological and obese conditions. All consistent and inconsistent findings are discussed and further studies aiming to fill any gaps in the knowledge are proposed.

• Authors: Yanee Choksomngam, Sintip Pattanakuhar, Nipon Chattipakorn, Siriporn C Chattipakorn
• Journal: Obesity research & clinical practice (Obes Res Clin Pract) 2021 Jul-Aug Vol. 15 Issue 4 Pg. 315-326 ISSN: 1871-403X [Print] Netherlands
• PMID: 34217652 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2021 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.

Chemical References

• Polyamines
• Glucose
• Spermidine

Topics

• Animals
• Child
• Diabetes Mellitus, Type 2 (etiology)
• Glucose
• Humans
• Pediatric Obesity
• Polyamines
• Spermidine