Panaxytriol Inhibits Lipopolysaccharide-Induced Microglia Activation in Brain Inflammation in Vivo.

Abstract

Brain inflammation is a pathological characteristic of neurodegenerative diseases. In this condition, excessively activated microglia elevate proinflammatory mediator levels. We previously reported that panaxytriol inhibited lipopolysaccharide (LPS)-induced microglia activation in vitro. However, the effects of panaxytriol on microglia activation in vivo require confirmation. In the present study, we found that panaxytriol suppressed both microglia and astrocyte activation by injected LPS intracerebrally to mice with LPS-induced brain inflammation. Panaxytriol was more effective on microglia than astrocytes. Moreover, panaxytriol tended to reduce LPS-induced spontaneous motor activity dysfunction. These results suggested that panaxytriol could improve brain health by suppressing microglia activation in neurodegenerative diseases.

• Authors: Genki Hiramatsu, Kosuke Matsuda, Daisuke Uta, Kenichi Mihara, Toshiaki Kume
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 44 Issue 7 Pg. 1024-1028 ( 2021) ISSN: 1347-5215 [Electronic] Japan
• PMID: 34193685 (Publication Type: Journal Article)

Chemical References

• Enediynes
• Fatty Alcohols
• Lipopolysaccharides
• Neuroprotective Agents
• panaxytriol

Topics

• Animals
• Astrocytes (drug effects)
• Encephalitis (drug therapy)
• Enediynes (pharmacology, therapeutic use)
• Fatty Alcohols (pharmacology, therapeutic use)
• Hippocampus (drug effects)
• Lipopolysaccharides (pharmacology)
• Locomotion (drug effects)
• Mice, Inbred C57BL
• Microglia (drug effects)
• Neuroprotective Agents (pharmacology, therapeutic use)