Multicenter Study of Carbon-ion Radiotherapy for Oropharyngeal Non-squamous Cell Carcinoma.

Abstract

BACKGROUND/AIM:

To evaluate treatment outcomes of carbon-ion radiotherapy for oropharyngeal non-squamous cell carcinoma at four carbon-ion facilities in Japan.

PATIENTS AND METHODS:

We retrospectively analyzed the cases of 33 patients with oropharyngeal non-squamous cell carcinoma who were treated with carbon-ion radiotherapy between November 2003 and December 2014.

RESULTS:

The histology included adenoid cystic carcinoma (n=25) and mucosal malignant melanoma (n=4). No patients had T1 tumors; 23 had T4 tumors. The most-commonly prescribed dose was 57.6 Gy (RBE) in 16 fractions. The median follow-up period was 34.8 months (range=4.2-122.8 months). The 3-year local control and overall survival rates were 94.7% and 90.7%, respectively. There were no grade ≥4 acute adverse events. Only one patient experienced a grade ≥4 late adverse event. No patients experienced late adverse events related to swallowing or salivary function.

CONCLUSION:

Carbon-ion radiotherapy appears to be a promising treatment option for oropharyngeal non-squamous cell carcinoma.

• Authors: Takashi Kaneko, Hiroaki Suefuji, Masashi Koto, Yusuke Demizu, Jun-Ichi Saitoh, Hiroshi Tsuji, Tomoaki Okimoto, Tatsuya Ohno, Yoshiyuki Shioyama, Kenji Nemoto, Takashi Nakano, Tadashi Kamada
• Journal: In vivo (Athens, Greece) (In Vivo) 2021 Jul-Aug Vol. 35 Issue 4 Pg. 2239-2245 ISSN: 1791-7549 [Electronic] Greece
• PMID: 34182502 (Publication Type: Journal Article, Multicenter Study)
• Copyright: Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• Carbon

Topics

• Carbon
• Head and Neck Neoplasms
• Heavy Ion Radiotherapy (adverse effects)
• Humans
• Japan
• Retrospective Studies