RIFM fragrance ingredient safety assessment, 1-heptanethiol, CAS Registry Number 1639-09-4.

Abstract

1-Heptanethiol was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog 1-octanethiol (CAS # 111-88-6) show that 1-heptanethiol is not expected to be genotoxic and provide a calculated MOE >100 for the reproductive toxicity endpoint. Data on read-across analog dodecanethiol (CAS # 112-55-0) provide a calculated MOE >100 for the repeated dose toxicity endpoint. Data show that there are no safety concerns for 1-heptanethiol for skin sensitization under the current declared levels of use. The phototoxicity/photoallergenicity endpoints were evaluated based on UV/Vis spectra for read-across analog methyl mercaptan (CAS # 74-93-1); 1-heptanethiol is not expected to be phototoxic/photoallergenic. The local respiratory toxicity endpoint was evaluated using the TTC for a Cramer Class I material; exposure is below the TTC (1.4 mg/day). The environmental endpoints were evaluated; 1-heptanethiol was found not to be PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC), are <1.

• Authors: A M Api, D Belsito, S Biserta, D Botelho, M Bruze, G A Burton Jr, J Buschmann, M A Cancellieri, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, S Gadhia, L Jones, K Joshi, M Kumar, A Lapczynski, M Lavelle, I Lee, D C Liebler, H Moustakas, M Na, T M Penning, G Ritacco, J Romine, N Sadekar, T W Schultz, D Selechnik, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura
• Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 153 Suppl 1 Pg. 112360 (Jul 2021) ISSN: 1873-6351 [Electronic] England
• PMID: 34182040 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2021 Elsevier Ltd. All rights reserved.

Chemical References

• Heptanes
• Perfume
• Sulfhydryl Compounds

Topics

• Animals
• Bacteria (drug effects)
• Consumer Product Safety
• Endpoint Determination
• Heptanes (toxicity)
• Humans
• No-Observed-Adverse-Effect Level
• Odorants
• Perfume (toxicity)
• Risk Assessment
• Sulfhydryl Compounds (toxicity)