Abstract |
The antiemetic efficacy of high-dose metoclopramide (MCP), diphenhydramine (DPH), methylprednisolone (MPL), and diazepam (DZP) was investigated in 40 gynecologic cancer patients for a total of 98 chemotherapy courses, treated with cisplatin (50 mg/m2). With MPL (500 mg i.v. x 2) plus DZP (5 mg i.m. x 2), no vomiting occurred in 0% and mild emesis ( vomiting 1-2 times) occurred in 20% of 25 courses. With MCP (2 mg/kg i.v. x 5) plus DPH (40 mg i.v. x 3), no vomiting occurred in 35% and mild emesis occurred in 10% of 20 courses. With a combination of MCP plus DPH and MPL plus DZP, no vomiting occurred in 51% and mild emesis occurred in 25% of 53 courses. These results indicate that high-dose MCP plus DPH are effective in preventing cisplatin-induced vomiting. Furthermore, the antiemetic efficacy of MCP plus DPH (0-2 vomiting episodes: 45%) was significantly enhanced (p less than 0.05) by the combined use of MPL plus DZP (0-2 vomiting episodes: 76%).
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Authors | Y Hayashi, T Iwasaka, T Hachisuga, K Fukuda, T Tanaka, N Matsuo, H Sugimori |
Journal | Nihon Sanka Fujinka Gakkai zasshi
(Nihon Sanka Fujinka Gakkai Zasshi)
Vol. 40
Issue 7
Pg. 875-9
(Jul 1988)
ISSN: 0300-9165 [Print] Japan |
PMID | 3418195
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Diphenhydramine
- Metoclopramide
- Cisplatin
- Diazepam
- Methylprednisolone
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Topics |
- Adult
- Aged
- Cisplatin
(adverse effects)
- Diazepam
(administration & dosage)
- Diphenhydramine
(administration & dosage)
- Drug Therapy, Combination
- Female
- Genital Neoplasms, Female
(drug therapy)
- Humans
- Methylprednisolone
(administration & dosage)
- Metoclopramide
(administration & dosage)
- Middle Aged
- Vomiting
(chemically induced, drug therapy)
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