A masked, randomised clinical trial evaluating the efficacy and safety of lokivetmab compared to saline control in client-owned dogs with allergic dermatitis.

Abstract

BACKGROUND:

Interleukin (IL)-31 is an important mediator in canine atopic dermatitis (cAD) and also may be dysregulated in other allergic diseases.

HYPOTHESIS/OBJECTIVES:

To demonstrate the efficacy and safety of lokivetmab (canine anti-IL-31 monoclonal antibody) for treatment of pruritus associated with allergic dermatitis in dogs.

ANIMALS:

Dogs that were at least moderately pruritic with a presumptive diagnosis of allergic dermatitis were enrolled in Portugal, Hungary, France and Germany by 12 primary care practitioners and two veterinary dermatology referral specialists.

METHODS AND MATERIALS:

Dogs were randomised to receive either placebo (saline) or lokivetmab (1.0-3.3 mg/kg) by subcutaneous injection on Day (D)0. Owners evaluated pruritus using a validated Visual Analog Scale (pVAS) daily until D7 and then weekly until D28. The severity of dermatitis was assessed by the investigators using a modified VAS on D0, D7, D14 and D28.

RESULTS:

Beginning at D1, owner-assessed pVAS least square means were significantly reduced in the treatment group versus the placebo group (57.7% versus 21.8% reduction on D28). For all time points, investigator-assessed VAS means were significantly reduced in the lokivetmab group versus the placebo group (57.1% versus 20.5% reduction on D28). Overall, the occurrence of adverse health events during the evaluation period was comparable between the two groups.

CONCLUSIONS AND CLINICAL IMPORTANCE:

Lokivetmab is a safe and efficacious treatment for dogs with allergic dermatitis.

• Authors: Leen Van Brussel, Hilde Moyaert, Monica Escalada, Sean P Mahabir, Michael R Stegemann
• Journal: Veterinary dermatology (Vet Dermatol) Vol. 32 Issue 5 Pg. 477-e131 (Oct 2021) ISSN: 1365-3164 [Electronic] England
• PMID: 34180084 (Publication Type: Journal Article, Randomized Controlled Trial, Veterinary)
• Copyright: © 2021 Zoetis. Veterinary Dermatology published by John Wiley & Sons Ltd on behalf of the European Society of Veterinary Dermatology and The American College of Veterinary Dermatology.

Chemical References

• Antibodies, Monoclonal
• lokivetmab

Topics

• Animals
• Antibodies, Monoclonal
• Dermatitis, Atopic (drug therapy, veterinary)
• Dog Diseases (drug therapy)
• Dogs
• Pruritus (veterinary)