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Extrapyramidal syndrome and depression induced by flunarizine.

Abstract
Apathy, mood depression and extrapyramidal signs consisting of akinesia, amimia, gait apraxia, slight rigidity and tremor were induced in 10 patients by long-term treatment with flunarizine for trivial complaints. These symptoms suggest a mild antidopaminergic activity of flunarizine. Long-term administration of flunarizine should be avoided particularly in the elderly and in patients with extrapyramidal disorders.
AuthorsA Lugaresi, P Montagna, R Gallassi, E Lugaresi
JournalEuropean neurology (Eur Neurol) Vol. 28 Issue 4 Pg. 208-11 ( 1988) ISSN: 0014-3022 [Print] Switzerland
PMID3416889 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Flunarizine
Topics
  • Aged
  • Basal Ganglia Diseases (chemically induced, complications, physiopathology)
  • Depression (chemically induced, complications, physiopathology)
  • Female
  • Flunarizine (adverse effects)
  • Humans
  • Male
  • Middle Aged

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