Abstract |
Apathy, mood depression and extrapyramidal signs consisting of akinesia, amimia, gait apraxia, slight rigidity and tremor were induced in 10 patients by long-term treatment with flunarizine for trivial complaints. These symptoms suggest a mild antidopaminergic activity of flunarizine. Long-term administration of flunarizine should be avoided particularly in the elderly and in patients with extrapyramidal disorders.
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Authors | A Lugaresi, P Montagna, R Gallassi, E Lugaresi |
Journal | European neurology
(Eur Neurol)
Vol. 28
Issue 4
Pg. 208-11
( 1988)
ISSN: 0014-3022 [Print] Switzerland |
PMID | 3416889
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Aged
- Basal Ganglia Diseases
(chemically induced, complications, physiopathology)
- Depression
(chemically induced, complications, physiopathology)
- Female
- Flunarizine
(adverse effects)
- Humans
- Male
- Middle Aged
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