Quantitative Analysis of Tranexamic Acid Effects on Ecchymosis in Rhinoplasty.

Abstract

Background: Many methods have been described to reduce postoperative ecchymosis in rhinoplasty with tranexamic acid (TXA) remaining controversial. TXA remains a consideration for surgeons, however, may have serious side effects, including seizures, blood clots, and vision changes. Methods: A prospective study of primary rhinoplasty patients was performed from March 2019 to June 2019. TXA was used in 50 patients and postoperative ecchymosis was compared with 50 control patients. Adobe Photoshop was used to quantitate postoperative ecchymosis using multiple objective color scales. Results: One hundred subjects were enrolled in the study. Eighty-four females and 16 males were included. Photographs were taken on postoperative day 7. There were no significant differences among any of the Red, Green, Blue (RGB) and L*a*b* color subgroups with p > 0.05. There were no adverse events with TXA. Conclusions: In this study, TXA did not reduce postoperative ecchymosis in rhinoplasty when used both through intravenous and intraoperative injections.

• Authors: Robert T Cristel, Daniel Demesh, Manish J Patel, Anil R Shah
• Journal: Facial plastic surgery & aesthetic medicine (Facial Plast Surg Aesthet Med) 2022 May-Jun Vol. 24 Issue 3 Pg. 228-232 ISSN: 2689-3622 [Electronic] United States
• PMID: 34166107 (Publication Type: Journal Article)

Chemical References

• Tranexamic Acid

Topics

• Ecchymosis (drug therapy, etiology, prevention & control)
• Edema (drug therapy)
• Female
• Humans
• Male
• Postoperative Complications (etiology, prevention & control)
• Prospective Studies
• Rhinoplasty (methods)
• Tranexamic Acid (therapeutic use)