Abstract | BACKGROUND: METHODS: We performed a secondary analysis of data from a randomized, controlled trial comparing oxygenation strategies in 549 patients with ARDS (NCT00000579). Baseline 25OHD was measured in stored plasma samples. We investigated the relationship between vitamin D status and ventilator-free days (VFD) as well as 90-day survival, using linear regression and Cox proportional hazard models, respectively. Analyses were adjusted for age, race, and Acute Physiology and Chronic Health Evaluation III score. RESULTS: Baseline 25OHD was measured in 476 patients. 90% of these individuals had 25OHD <20 ng/ml and 40% had 25OHD <10 ng/ml. Patients with 25OHD <20 ng/ml were likely to be ventilated for 3 days longer than patients with levels ≥20 ng/ml (ß 3.41; 95%CI 0.42-6.39: P = 0.02). Patients with 25OHD <10 ng/ml were likely to be ventilated for 9 days longer (ß 9.27; 95%CI 7.24-11.02: P < 0.001) and to have a 34% higher risk of 90-day mortality (HR 1.34; 95% CI 1.06-1.71: P = 0.02) compared to patients with levels >10 ng/ml. CONCLUSIONS: In patients with ARDS, vitamin D status is associated with duration of mechanical ventilation and 90-day mortality. Randomized, controlled trials are warranted to determine whether vitamin D supplementation improves clinical outcomes in ARDS patients.
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Authors | Sadeq A Quraishi, Ishir Bhan, Michael A Matthay, Boyd T Thompson, Carlos A Camargo Jr, Ednan K Bajwa |
Journal | Journal of intensive care medicine
(J Intensive Care Med)
Vol. 37
Issue 6
Pg. 793-802
(Jun 2022)
ISSN: 1525-1489 [Electronic] United States |
PMID | 34165010
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Humans
- Lung Injury
- Respiration, Artificial
(adverse effects)
- Respiratory Distress Syndrome
(therapy)
- Tidal Volume
- Vitamin D
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