Abstract | BACKGROUND AND PURPOSE: METHODS: TDNP, with capacities of active targeting for tumors and controlled drug release, was prepared to co-deliver cisplatin and paclitaxel prodrugs. The characteristics were investigated, including the diameter, surface zeta potential, stability and tumor microenvironment (TME) dependent drug release profiles. Cellular uptake, cytotoxicity, drug accumulation in tumors, antitumor effects and safety analysis were evaluated in vitro and in vivo. RESULTS: The oxidized cisplatin and the paclitaxel linked to the polymer achieved a high loading effciency of over 80% and TME-dependent sustained drug release. Moreover, TMTP1 modification enhanced cellular uptake of TDNP and further improved the cytotoxicity of TDNP in vitro. In vivo, TDNP showed an extended blood circulation and increased accumulation in SiHa xenograft models with the aid of TMTP1. More importantly, TDNP controlled tumor growth without life-threatening side effects. CONCLUSION: Our study provided a novel TP co-delivery platform for targeted chemotherapy of cervical cancer, which was promising to improve the therapeutic effcacy of TP and may also have application in other tumors.
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Authors | Guiying Jiang, Xueqian Wang, Ying Zhou, Chenming Zou, Ling Wang, Wei Wang, Danya Zhang, Hanjie Xu, Jie Li, Fei Li, Danfeng Luo, Xiangyi Ma, Ding Ma, Songwei Tan, Rui Wei, Ling Xi |
Journal | International journal of nanomedicine
(Int J Nanomedicine)
Vol. 16
Pg. 4087-4104
( 2021)
ISSN: 1178-2013 [Electronic] New Zealand |
PMID | 34163161
(Publication Type: Journal Article)
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Copyright | © 2021 Jiang et al. |
Chemical References |
- Drug Carriers
- Polymers
- Prodrugs
- Paclitaxel
- Cisplatin
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Topics |
- Animals
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, metabolism, pharmacology)
- Cell Line, Tumor
- Cisplatin
(administration & dosage, metabolism, pharmacology)
- Drug Carriers
(chemistry)
- Female
- Humans
- Nanoparticles
(chemistry)
- Paclitaxel
(administration & dosage, metabolism, pharmacology)
- Polymers
(chemistry)
- Prodrugs
(metabolism)
- Tumor Microenvironment
(drug effects)
- Uterine Cervical Neoplasms
(drug therapy)
- Xenograft Model Antitumor Assays
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