Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study.

Abstract

Corticosteroids reduced mortality rate in patients with coronavirus disease 2019 (COVID-19). Previously, we hypothesized that corticosteroids mitigate the inflammation response resulting in reduced coagulation and thrombosis. In this retrospective study, we included 27 patients with COVID-19 that received high-dose corticosteroids (methylprednisolone 1000 mg i.v. daily for 3 days) for persistent respiratory failure or an excessive inflammation response. We found that inflammation, coagulation, and ventilation parameters improved significantly after methylprednisolone. The viral loads of SARS-CoV-2 remained stable or decreased. These results provides insight into the reduced mortality rate observed in patients with COVID-19 treated with corticosteroids.

• Authors: Katja Tromp, Philip van der Zee, Casper Rokx, Jeroen van Kampen, Diederik Gommers, Henrik Endeman
• Journal: Biomarker insights (Biomark Insights) Vol. 16 Pg. 11772719211021647 ( 2021) ISSN: 1177-2719 [Print] United States
• PMID: 34158797 (Publication Type: Journal Article)
• Copyright: © The Author(s) 2021.