Abstract | BACKGROUND: OBJECTIVES: The current study aimed to investigate the effect of adding ozone gas to hypertonic dextrose and somatropin for knee prolotherapy in patients with knee OA. For this purpose, pain, knee stiffness, and physical activity are measured. METHODS: Sixty patients with chronic knee OA were randomly assigned into two groups of DS and DSO. The DS group received intra-articular hypertonic dextrose (10 ml) plus 4 IU somatropin (4 IU), and the DSO group received 10 ml ozone 25 mcg plus intervention in the DS group. This procedure was performed three times (first, third, and fifth weeks). WOMAC score was examined during the third, fifth, and sixteenth weeks. RESULTS: The mean WOMAC score of the DS group was decreased significantly (P < 0.001) sixteen weeks after providing the intervention (before 64.9 ± 10.6, vs. after 49.2 ± 9.0). A similar decrease (P < 0.001) was observed in the DSO group (before 64.1 ± 11.3, vs. after 41.3 ± 8.0). The decrease of the WOMAC score in the third and sixteenth weeks after providing the intervention was significant in the DSO group compared to the DS group (P < 0.005). CONCLUSIONS:
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Authors | Farnad Imani, Kokab Hejazian, Mohammad-Reza Kazemi, Mahnaz Narimani-Zamanabadi, Khalid M Malik |
Journal | Anesthesiology and pain medicine
(Anesth Pain Med)
Vol. 10
Issue 5
Pg. e110277
(Oct 2020)
ISSN: 2228-7523 [Print] Netherlands |
PMID | 34150571
(Publication Type: Journal Article)
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Copyright | Copyright © 2020, Author(s). |