Abstract | AIMS: MATERIALS AND METHODS: Rabbits were arranged in 3 groups: Group 1 (Control): regular rabbit chow; Group 2 (HCD): 1% cholesterol-enriched chow was given to rabbits for 4 weeks; Group 3 (HCD-CANA): 1% cholesterol-enriched chow was fed to rabbits concurrently with canagliflozin (10 mg/kg/day, orally) for 4 weeks. At the end of experiment, blood and tissue samples were obtained for biochemical, histological, immunohistochemical, and vascular reactivity assessment. KEY FINDINGS: SIGNIFICANCE:
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Authors | Nora A Ashry, Rania R Abdelaziz, Ghada M Suddek, Mohamed A Saleh |
Journal | Life sciences
(Life Sci)
Vol. 280
Pg. 119731
(09 01 2021)
ISSN: 1879-0631 [Electronic] Netherlands |
PMID | 34144054
(Publication Type: Journal Article)
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Copyright | Copyright © 2021 Elsevier Inc. All rights reserved. |
Chemical References |
- Cholesterol, Dietary
- Hypoglycemic Agents
- Lipids
- Sodium-Glucose Transporter 2 Inhibitors
- Canagliflozin
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Topics |
- Animals
- Aorta
(drug effects, physiopathology)
- Canagliflozin
(therapeutic use)
- Cholesterol, Dietary
(adverse effects)
- Hypercholesterolemia
(blood, drug therapy, etiology, physiopathology)
- Hypoglycemic Agents
(therapeutic use)
- Lipids
(blood)
- Liver
(drug effects, physiopathology)
- Male
- Rabbits
- Sodium-Glucose Transporter 2 Inhibitors
(therapeutic use)
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