In Situ Self-Organizing Materials for Local Stress-Responsive Reconstruction of Skin Interstitium.

Abstract

Remodeling of the fibrous network in the skin interstitium is a crucial step in the process of skin wound healing. In the present study, a hierarchically structured xanthan gum-chitosan (XG-CS) composite hydrogel is developed as a skin wound healing material that responds to stress at wound sites by in situ self-organizing and self-repairing the interstitial fibrous network. The composite gel adheres tightly to the injured fibers forming an intact interstitial pathway, and thereby promotes the physiological function of fibroblasts. A software-based quantitative assessment is performed to evaluate the stress state at wound sites, which confirms that the composite gel adapted in vivo to wound stress and ultimately promotes fast wound healing. The results highlight the importance of interstitial reconstruction in tissue recovery, and will inspire novel strategies in regenerative medicine.

• Authors: Xinxiao Han, Wenda Hua, Yuqi Liu, Zhuo Ao, Dong Han
• Journal: Macromolecular bioscience (Macromol Biosci) Vol. 21 Issue 8 Pg. e2100119 (08 2021) ISSN: 1616-5195 [Electronic] Germany
• PMID: 34142427 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2021 Wiley-VCH GmbH.

Chemical References

• Hydrogels
• Chitosan

Topics

• Chitosan (pharmacology)
• Fibroblasts (metabolism)
• Hydrogels (pharmacology)
• Skin
• Wound Healing