Aclidinium bromide/formoterol fumarate as a treatment for COPD: an update.

Abstract

Introduction: Aclidinium/formoterol is a long-acting muscarinic antagonist (LAMA) and long-acting β2-agonist (LABA) dual bronchodilator used as a maintenance treatment for patients with chronic obstructive pulmonary disease (COPD). The efficacy of aclidinium/formoterol has been demonstrated consistently in patients with moderate-to-severe COPD versus placebo and monocomponents, with a comparable safety profile.Areas covered: This review examines recent research findings that expand our understanding of the impact of aclidinium/formoterol on the burden of COPD. Reviewed outcomes include improvements in lung function, respiratory symptoms, health-related quality of life, exercise tolerance, exacerbation rates, and clinically important deteriorations. In addition, the reported cardiovascular safety of aclidinium and current LAMA/LABA treatment recommendations are discussed.Expert opinion: Aclidinium/formoterol reduces disease burden in patients with COPD, including those that are treatment-naïve, without a significant increase in safety risk compared with monotherapies. Furthermore, evidence supports an improvement in lung function over a 24-hour period with aclidinium/formoterol treatment versus monotherapy and placebo, which may offer an advantage over some once-daily LAMA/LABA combinations. In summary, the recent evidence discussed in this review adds weight to the use of LAMA/LABA combinations as an initial therapy for certain patients newly diagnosed with COPD.

• Authors: Anthony D D'Urzo, Dave Singh, James F Donohue, Kenneth R Chapman, Robert A Wise
• Journal: Expert review of respiratory medicine (Expert Rev Respir Med) Vol. 15 Issue 9 Pg. 1093-1106 (09 2021) ISSN: 1747-6356 [Electronic] England
• PMID: 34137664 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Adrenergic beta-2 Receptor Agonists
• Bronchodilator Agents
• Drug Combinations
• Tropanes
• aclidinium bromide
• Formoterol Fumarate

Topics

• Adrenergic beta-2 Receptor Agonists (therapeutic use)
• Bronchodilator Agents (therapeutic use)
• Drug Combinations
• Formoterol Fumarate (therapeutic use)
• Humans
• Pulmonary Disease, Chronic Obstructive (diagnosis, drug therapy)
• Quality of Life
• Tropanes