Serum galectin-3 levels in patients with psoriasis.

Abstract

INTRODUCTION:

Galectin-3 is a β-galactoside-binding lectin associated with cellular proliferation, inflammation and angiogenesis, which are the major characteristics of psoriatic skin.

OBJECTIVES:

To investigate serum galectin-3 levels in psoriasis patients compared with healthy controls and to study its relationship with disease characteristics.

METHODS:

Seventy-eight patients diagnosed with psoriasis and 78 age- and sex-matched healthy volunteers were included in the study. Serum galectin-3, IL-17, IL-6 and TNF-α levels were measured using Enzyme-linked immunosorbent assay (ELISA).

RESULTS:

Serum Galectin-3, IL-17, IL-6 and TNF-α levels were significantly higher in psoriasis patients compared with control group (P < .001, P = .003, P < .001 and P < .001, respectively). A cut-off value of 10 ng/mL for galectin-3 was set after receiver operating characteristic analysis. A serum galectin-3 level >10 ng/mL increased the risk of psoriasis by 14.5 times (95% CI: 6.6-32.3, P < .001) and a serum galectin-3 level >10 ng/mL predicted psoriasis with 83.3% sensitivity and 74.3% specificity. No statistically significant association was observed between serum galectin-3 concentrations and disease characteristics including disease severity, presence of psoriatic arthritis, nail involvement and psoriatic comorbidity. No statistically significant correlation was observed between serum galectin-3 level and serum IL-17, IL-6 and TNF-α levels (all three P values > .05).

CONCLUSIONS:

Elevated serum galectin-3 levels in psoriasis patients may indicate a possible role of galectin-3 in pathogenesis of psoriasis.

• Authors: Yıldız Hayran, Nuran Allı, Ümit Akpınar, Ayşe Öktem, Çiğdem Yücel, Esra Fırat Oguz, Turan Turhan
• Journal: International journal of clinical practice (Int J Clin Pract) Vol. 75 Issue 10 Pg. e14545 (Oct 2021) ISSN: 1742-1241 [Electronic] India
• PMID: 34137138 (Publication Type: Journal Article)
• Copyright: © 2021 John Wiley & Sons Ltd.

Chemical References

• Blood Proteins
• Galectin 3
• Galectins
• LGALS3 protein, human
• Tumor Necrosis Factor-alpha

Topics

• Blood Proteins
• Case-Control Studies
• Galectin 3
• Galectins
• Humans
• Psoriasis
• ROC Curve
• Severity of Illness Index
• Tumor Necrosis Factor-alpha