Abstract | Background: Materials and Methods: We enrolled 60 reproductive-aged (15-45 years) women with pelvic pain in this triple-blind clinical trial. They had 1-3 stages of laparoscopic-proven endometriosis. The participants were randomized to group A (n = 30), given vitamin C (1000 mg/day, 2 tablets of 500 mg each) and vitamin E (800 IU/day, 2 tablets of 400 IU each) combination, or group B (n = 30), given placebo pills daily for 8 weeks. Results: Following treatment with vitamin C and vitamin E, we found a significant reduction in MDA and ROS compared with the placebo group. There was no significant decline in total antioxidant capacity after treatment. However, the severity of pelvic pain (p value <0.001), dysmenorrhea (p value <0.001), and dyspareunia (p value <0.001) significantly decreased in the treatment group after 8 weeks of supplementation. Conclusions:
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Authors | Leila Amini, Razieh Chekini, Mohammad Reza Nateghi, Hamid Haghani, Tannaz Jamialahmadi, Thozhukat Sathyapalan, Amirhossein Sahebkar |
Journal | Pain research & management
(Pain Res Manag)
Vol. 2021
Pg. 5529741
( 2021)
ISSN: 1918-1523 [Electronic] United States |
PMID | 34122682
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2021 Leila Amini et al. |
Chemical References |
- Antioxidants
- Biomarkers
- Vitamin E
- Ascorbic Acid
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Topics |
- Adult
- Antioxidants
(therapeutic use)
- Ascorbic Acid
(therapeutic use)
- Biomarkers
(metabolism)
- Dietary Supplements
(analysis)
- Endometriosis
(drug therapy, etiology)
- Female
- Humans
- Middle Aged
- Oxidative Stress
(drug effects)
- Pain Management
(methods)
- Vitamin E
(therapeutic use)
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