Abstract | PURPOSE: To evaluate the safety and efficacy of preservative-free (PF) latanoprost in glaucoma patients. METHODS: In this prospective, open-label, observational study, a total of 27 primary open-angle glaucoma patients who used benzalkonium chloride-preserved prostaglandin analogues for at least 6 months were enrolled. After changing the eye drops to PF lataprost, the intraocular pressure (IOP) and ocular surface symptoms and signs were evaluated in all patients on days 0 (first visit, D0), 45 (D45), and 90 (D90). RESULTS: Mean IOP remained stable during the study period (14.0 ± 2.4 mmHg at D0, 13.9 ± 2.0 mmHg at D45, 13.7 ± 2.2 mmHg at D90; p = 0.603). Mean deviation, pattern standard deviation, and best-corrected visual acuity were similar before and after eye drops replacement. Bulbar conjunctival hyperemia, corneal staining, and conjunctival staining were significantly decreased over 90 days (p = 0.025, p < 0.001, p = 0.020, respectively). The ocular surface disease index score showed a statistically significant improvement from 26.4 ± 18.5 at D0 to 19.8 ± 17.0 at D45 and 15.7 ± 15.6 at D90 (p < 0.001). In the evaluation of ocular tolerability, burning symptoms and dryness were significantly decreased (p = 0.001, p = 0.040). CONCLUSIONS:
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Authors | Hyo Jin Seong, Kwanghyun Lee, Seung Jae Lee, Sangah Kim, Jong Woon Park |
Journal | Korean journal of ophthalmology : KJO
(Korean J Ophthalmol)
Vol. 35
Issue 3
Pg. 235-241
(06 2021)
ISSN: 2092-9382 [Electronic] Korea (South) |
PMID | 34120423
(Publication Type: Journal Article, Observational Study)
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Chemical References |
- Antihypertensive Agents
- Ophthalmic Solutions
- Preservatives, Pharmaceutical
- Prostaglandins F, Synthetic
- Prostaglandins, Synthetic
- Latanoprost
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Topics |
- Antihypertensive Agents
(therapeutic use)
- Glaucoma, Open-Angle
(drug therapy)
- Humans
- Intraocular Pressure
- Latanoprost
- Ocular Hypertension
- Ophthalmic Solutions
- Preservatives, Pharmaceutical
- Prospective Studies
- Prostaglandins F, Synthetic
- Prostaglandins, Synthetic
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