Abstract |
Mycobacterium abscessus subsp. abscessus is one of the most difficult pathogens to treat and its incidence in disease is increasing. Dual β- lactam combinations act synergistically in vitro but are not widely employed in practice. A recent study shows that a combination of imipenem and ceftaroline significantly lowers the minimum inhibitory concentration of clinical isolates, despite both drugs targeting the same peptidoglycan synthesis enzymes. The underlying mechanism of this effect provides a basis for further investigations of dual β- lactam combinations in the treatment of M. abscessus subsp. abscessus, eventually leading to a clinical trial. Furthermore, dual β- lactam strategies may be explored for other difficult mycobacterial infections.
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Authors | David C Nguyen, Khalid M Dousa, Sebastian G Kurz, Sheldon T Brown, George Drusano, Steven M Holland, Barry N Kreiswirth, W Henry Boom, Charles L Daley, Robert A Bonomo |
Journal | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
(Clin Infect Dis)
Vol. 73
Issue 8
Pg. 1532-1536
(10 20 2021)
ISSN: 1537-6591 [Electronic] United States |
PMID | 34113990
(Publication Type: Journal Article)
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Copyright | © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected]. |
Chemical References |
- Anti-Bacterial Agents
- Lactams
- Peptidoglycan
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Topics |
- Anti-Bacterial Agents
(pharmacology)
- Drug Synergism
- Humans
- Lactams
- Microbial Sensitivity Tests
- Mycobacterium Infections, Nontuberculous
(drug therapy)
- Mycobacterium abscessus
- Peptidoglycan
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