Atremorine is a novel bioproduct obtained by nondenaturing biotechnological processes from a genetic species of Vicia faba.
Atremorine is a potent
dopamine (DA) enhancer with powerful effects on the neuronal dopaminergic system, acting as a
neuroprotective agent in
Parkinson's disease (PD). Over 97% of PD patients respond to a single dose of
Atremorine (5 g, p.o.) 1 h after administration. This response is gender-, time-, dose-, and genotype-dependent, with optimal doses ranging from 5 to 20 g/day, depending upon disease severity and concomitant medication.
Drug-free patients show an increase in DA levels from 12.14 ± 0.34 pg/ml to 6463.21 ± 1306.90 pg/ml; and patients chronically treated with anti-PD drugs show an increase in DA levels from 1321.53 ± 389.94 pg/ml to 16,028.54 ± 4783.98 pg/ml, indicating that
Atremorine potentiates the
dopaminergic effects of conventional anti-PD drugs.
Atremorine also influences the levels of other
neurotransmitters (
adrenaline,
noradrenaline) and
hormones which are regulated by DA (e.g.,
prolactin, PRL), with no effect on
serotonin or
histamine. The variability in
Atremorine-induced DA response is highly attributable to pharmacogenetic factors. Polymorphic variants in pathogenic (SNCA, NUCKS1, ITGA8, GPNMB, GCH1, BCKDK,
APOE, LRRK2, ACMSD), mechanistic (DRD2), metabolic (
CYP2D6,
CYP2C9,
CYP2C19,
CYP3A4/5, NAT2), transporter (ABCB1, SLC6A2, SLC6A3, SLC6A4) and pleiotropic genes (
APOE) influence the DA response to
Atremorine and its psychomotor and brain effects.
Atremorine enhances DNA methylation and displays epigenetic activity via modulation of the pharmacoepigenetic network.
Atremorine is a novel
neuroprotective agent for dopaminergic neurons with potential prophylactic and therapeutic activity in PD.