Eosinophilic Granulomatosis with Polyangiitis Presenting with Central Retinal Artery Occlusion During Treatment with Anti-interleukin-5 Receptor Monoclonal Antibody.

Abstract

Eosinophilic granulomatosis with polyangiitis (EGPA) is an anti-neutrophilic cytoplasm antibody (ANCA)-associated vasculitis characterized by asthma and eosinophilia. Although EGPA involves multiple organs, ocular involvement is infrequent and often carries a poor visual prognosis. We herein report a rare case of EGPA presenting with central retinal artery occlusion (CRAO) in which visual loss developed during treatment with anti-interleukin (IL)-5 receptor monoclonal antibody, and improvement in visual outcomes was attained after treatment combining high-dose oral corticosteroids, cyclophosphamide and an anticoagulant. Physicians should consider CRAO as an ophthalmic manifestation of EGPA in patients with severe eosinophilic asthma.

• Authors: Hirono Nishiyama, Tomoko Tajiri, Toru Yamabe, Tsutomu Yasukawa, Norihisa Takeda, Kensuke Fukumitsu, Satoshi Fukuda, Yoshihiro Kanemitsu, Takehiro Uemura, Hirotsugu Ohkubo, Masaya Takemura, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Taio Naniwa, Akio Niimi
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 60 Issue 22 Pg. 3631-3634 (Nov 15 2021) ISSN: 1349-7235 [Electronic] Japan
• PMID: 34092731 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Monoclonal
• Receptors, Interleukin-5

Topics

• Antibodies, Monoclonal
• Churg-Strauss Syndrome (complications, diagnosis, drug therapy)
• Granulomatosis with Polyangiitis
• Humans
• Receptors, Interleukin-5
• Retinal Artery Occlusion (chemically induced, diagnosis, drug therapy)