Uncurtaining the pivotal role of ABC transporters in diabetes mellitus.

Abstract

The metabolic disorders are the edge points for the initiation of various diseases. These disorders comprised of several diseases including diabetes, obesity, and cardiovascular complications. Worldwide, the prevalence of these disorders is increasing day by day. The world's population is at higher threat of developing metabolic disease, especially diabetes. Therefore, there is an impregnable necessity of searching for a newer therapeutic target to reduce the burden of these disorders. Diabetes mellitus (DM) is marked with the dysregulated insulin secretion and resistance. The lipid and glucose transporters portray a pivotal role in the metabolism and transport of both of these. The excess production of lipid and glucose and decreased clearance of these leads to the emergence of DM. The ATP-binding cassette transporters (ABCT) are important for the metabolism of glucose and lipid. Various studies suggest the key involvement of ABCT in the pathologic process of different diseases. In addition, the involvement of other pathways, including IGF signaling, P13-Akt/PKC/MAPK signaling, and GLP-1 via regulation of ABCT, may help develop new treatment strategies to cope with insulin resistance dysregulated glucose metabolism, key features in DM.

• Authors: Tapan Behl, Aayush Sehgal, Madhuri Grover, Sukhbir Singh, Neelam Sharma, Saurabh Bhatia, Ahmed Al-Harrasi, Lotfi Aleya, Simona Bungau
• Journal: Environmental science and pollution research international (Environ Sci Pollut Res Int) Vol. 28 Issue 31 Pg. 41533-41551 (Aug 2021) ISSN: 1614-7499 [Electronic] Germany
• PMID: 34085197 (Publication Type: Journal Article, Review)
• Copyright: © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Chemical References

• ATP-Binding Cassette Transporters
• Glucose

Topics

• ATP-Binding Cassette Transporters (genetics)
• Diabetes Mellitus
• Glucose
• Humans
• Insulin Resistance