[Morphological signs of the blocking effect of immunoglobulins and immune complexes in breast cancer before and after radiotherapy].

Abstract

Parenchyma of radiation-treated (48.0%) and untreated (47.9%) fibroadenomas, dysplasias, breast cancer (in 57.1%, 55.6% and 47.9% of cases, respectively) are shown to contain deposits of immune complexes (IC) and immunoglobulins (Ig) of the main classes. This may be an underlying cause of the blocked interaction between epithelial cells and lymphocytes supported by a significant reduction in the specific lymphocyte density observed for parenchyma of IC-positive fibroadenoma and dysplasia, breast cancer periphery occurring before radiation therapy. Poor long-term outcomes of IC-positive breast cancer irrespective of radiation treatment allow the author to refer IC and Ig deposits to criteria of unfavorable prognosis as well as indicators of breast cancer cells radioresistance.

• Authors: A E Dorosevich
• Journal: Arkhiv patologii (Arkh Patol) Vol. 50 Issue 4 Pg. 11-6 ( 1988) ISSN: 0004-1955 [Print] Russia (Federation)
• Vernacular Title: Morfologicheskoe proiavlenie blokiruiushchego deĭstviia immunoglobulinov i immunnykh kompleksov pri rake molochnoĭ zhelezy do i posle luchevogo lecheniia.
• PMID: 3408365 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antigen-Antibody Complex
• Receptors, Antigen, B-Cell

Topics

• Antigen-Antibody Complex (immunology, radiation effects)
• Binding, Competitive
• Breast Neoplasms (immunology, radiotherapy, ultrastructure)
• Female
• Humans
• Killer Cells, Natural (immunology, radiation effects)
• Prognosis
• Receptors, Antigen, B-Cell (immunology)