Associations of serum apolipoprotein A1, B levels and their ratio with blood pressure in Chinese adults with coronary artery disease.

Abstract

OBJECTIVE:

We examined the relationships of apolipoprotein A1 (ApoA1), ApoB levels and ApoB/A1 ratio with blood pressure (BP) in Chinese adults with coronary artery disease (CAD).

METHODS:

This cross-sectional study included 4921 adults with CAD. SBP, DBP, serum ApoA1 and ApoB levels were measured. The associations between Apo and BP were assessed by analyses of covariance.

RESULTS:

Serum ApoA1 was inversely associated with BP, whereas ApoB and the ApoB/A1 ratio exhibited positive associations with BP. For all subjects, a higher ApoA1 level was associated with lower SBP. Subjects in the fourth quartile for ApoA1 exhibited - 2.85 and - 2.63% lower DBP and mean arterial pressure (MAP), respectively than those in the third quartile. In contrast, higher ApoB and ApoB/A1 ratios were associated with higher SBP, DBP and MAP. The mean differences between ApoB quartiles 4 and 1 were 1.54% for SBP, 2.92% for DBP and 2.29% for MAP. The mean differences between the ApoB/A1 ratio quartiles 4 and 1 were 1.94% for SBP, 3.53% for DBP and 2.80% for MAP. In analyses stratified by gender, graded and inverse associations of ApoA1 with SBP, DBP and MAP were observed in both men and women, but positive associations were observed for ApoB and the ApoB/A1 ratio. Path analysis showed that BMI mediated the associations between ApoB and the ApoB/A1 ratio and SBP.

CONCLUSIONS:

In general, serum ApoA1 was inversely associated with BP in persons with CAD. In contrast, serum ApoB and the ApoB/A1 ratio were positively associated with BP, and these associations were mediated by BMI.

• Authors: Hongli Dong, Xuemei Yang, Yaju Zhang, Ping Hu, Yang Liu, Shuxia Liang
• Journal: Blood pressure monitoring (Blood Press Monit) Vol. 26 Issue 6 Pg. 401-406 (Dec 01 2021) ISSN: 1473-5725 [Electronic] England
• PMID: 34074807 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

Chemical References

• APOB protein, human
• Apolipoprotein A-I
• Apolipoprotein B-100

Topics

• Adult
• Apolipoprotein A-I (blood)
• Apolipoprotein B-100 (blood)
• Blood Pressure
• China
• Coronary Artery Disease (blood)
• Cross-Sectional Studies
• Female
• Humans
• Male