Abstract | BACKGROUND: METHODS: A systematic review of Medline and Embase databases was undertaken to identify all eligible studies with reference to thrombus viability in Wilms tumour index cases with caval/cardiac extension. A meta-analysis of proportions was utilized for pooled thrombus viability data across studies. Logistic regression was used to analyse the relationship between thrombus viability and duration of chemotherapy. RESULTS: Thirty-five eligible observational studies and case reports met inclusion criteria describing a total of 236 patients with thrombus viability data. The pooled proportion of patients with viable tumour thrombus after neoadjuvant chemotherapy was 0.53 (0.43-0.63). Logistic regression analysis of 54 patients receiving either a standard (4-6 weeks) or extended (more than 6 weeks) course of neoadjuvant chemotherapy resulted in an odds ratio of 3.14 (95 per cent c.i. 0.97 to 10.16), P = 0.056, with extended course therapy trending towards viable tumour thrombus. CONCLUSION: Preoperative chemotherapy is successful in achieving non-viability of caval and cardiac thrombi in around 50 per cent of children, without added benefit from extended cycles of neoadjuvant chemotherapy. Risks versus benefits of extirpative vascular surgery must be considered, therefore, for these high-risk patients.
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Authors | T D Boam, M Gabriel, R Shukla, P D Losty |
Journal | BJS open
(BJS Open)
Vol. 5
Issue 3
(05 07 2021)
ISSN: 2474-9842 [Electronic] England |
PMID | 34052849
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
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Copyright | © The Author(s) 2021. Published by Oxford University Press on behalf of BJS Society Ltd. |
Topics |
- Child
- Humans
- Kidney Neoplasms
(drug therapy)
- Neoadjuvant Therapy
- Retrospective Studies
- Thrombosis
(drug therapy)
- Vena Cava, Inferior
(surgery)
- Wilms Tumor
(drug therapy, surgery)
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