Liraglutide effects on glycemic control and weight in patients with type 2 diabetes Mellitus: A real-world, observational study and brief narrative review.

Abstract

BACKGROUND:

Glycemic control and weight gain are two essential considerations in the pharmacological management of type 2 diabetes mellitus. Pharmacological agents are effective in lowering blood glucose levels but may result in significant weight gain. Liraglutideeffectively maintains glycemic control while reducingweight.

METHODS:

This is a real-world study and brief narrative review of the effects of liraglutide on glycemic control and weight in adult patients with type 2 diabetes mellitus. The study uses data extracted from the electronic health record of the Ministry of National Guard-Health Affairs.

RESULTS:

In this study of 348 subjects, there was a statistically significant reduction in hemoglobin A1c of 0.9% (P < .0001) and weight of 2.3 kg (P < .0001). The majority (77.3%) were on concomitant insulin.Subjects with a baseline hemoglobin A1c greater than 9% had a significantly greater reduction than those below 9% (-0.7%;P < .0001). Those with a weight more than 100 kg had a significantly greater reduction than those below 100 kg (-0.9 kg;P = .0096).

CONCLUSION:

In this real-world, observational study, liraglutide was shown to be effective in improving glycemic control and reducing weight in adult patients with type 2 diabetes mellitus.

• Authors: Consuela Cheriece Yousef, Abin Thomas, Manar Al Matar, Lama Ghandoura, Ibrahim Aldossary, Sarah Musa Almuhanna, Fatimah Alhussain, Fatmh Bisher Al Bisher, Raneem Mohammad Aljohani, Alya Najeeb Balubaid, Mahmoud Ismail Nouh, Abdulhalim Almurashi, Reem AlAmoudi
• Journal: Diabetes research and clinical practice (Diabetes Res Clin Pract) Vol. 177 Pg. 108871 (Jul 2021) ISSN: 1872-8227 [Electronic] Ireland
• PMID: 34052248 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Chemical References

• Blood Glucose
• Glycated Hemoglobin A
• Hypoglycemic Agents
• Liraglutide

Topics

• Blood Glucose
• Diabetes Mellitus, Type 2 (drug therapy)
• Glycated Hemoglobin (analysis)
• Glycemic Control
• Humans
• Hypoglycemic Agents (therapeutic use)
• Liraglutide (therapeutic use)
• Observational Studies as Topic