Cyclin E in normal physiology and disease states.

Abstract

E-type cyclins, collectively called cyclin E, represent key components of the core cell cycle machinery. In mammalian cells, two E-type cyclins, E1 and E2, activate cyclin-dependent kinase 2 (CDK2) and drive cell cycle progression by phosphorylating several cellular proteins. Abnormally elevated activity of cyclin E-CDK2 has been documented in many human tumor types. Moreover, cyclin E overexpression mediates resistance of tumor cells to various therapeutic agents. Recent work has revealed that the role of cyclin E extends well beyond cell proliferation and tumorigenesis, and it may regulate a diverse array of physiological and pathological processes. In this review, we discuss these various cyclin E functions and the potential for therapeutic targeting of cyclin E and cyclin E-CDK2 kinase.

• Authors: Chen Chu, Yan Geng, Yu Zhou, Piotr Sicinski
• Journal: Trends in cell biology (Trends Cell Biol) Vol. 31 Issue 9 Pg. 732-746 (09 2021) ISSN: 1879-3088 [Electronic] England
• PMID: 34052101 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
• Copyright: Copyright © 2021 Elsevier Ltd. All rights reserved.

Chemical References

• Cyclin E
• Cyclins

Topics

• Animals
• Cell Cycle
• Cell Proliferation
• Cyclin E (genetics)
• Cyclins (genetics)
• Humans