Cholesterol gallstones: Focusing on the role of interstitial Cajal-like cells.

Abstract

Cholesterol gallstone (CG) is a common, frequent biliary system disease in China, with a complex and multifactorial etiology. Declined gallbladder motility reportedly contributes to CG pathogenesis. Furthermore, interstitial Cajal-like cells (ICLCs) are reportedly present in human and guinea pig gallbladder tissue. ICLCs potentially contribute to the regulation of gallbladder motility, and aberrant conditions involving the loss of ICLCs and/or a reduction in its pacing potential and reactivity to cholecystokinin may promote CG pathogenesis. This review discusses the association between ICLCs and CG pathogenesis and provides a basis for further studies on the functions of ICLCs and the etiologies of CG.

• Authors: Bei-Bei Fu, Jian-Nan Zhao, Shuo-Dong Wu, Ying Fan
• Journal: World journal of clinical cases (World J Clin Cases) Vol. 9 Issue 15 Pg. 3498-3505 (May 26 2021) ISSN: 2307-8960 [Print] United States
• PMID: 34046450 (Publication Type: Journal Article, Review)
• Copyright: ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.