Abstract | INTRODUCTION: METHODS: RESULTS: Serum oxalate levels were significantly increased in UA mice. Compared to the control mice, UA mice developed more areas of aortic calcification and showed significant increases in aortic oxalate levels and serum levels of oxidative stress markers and inflammatory factors. The correlation analysis showed that serum oxalate levels were positively correlated with the vascular oxalate levels and serum MDA, AOPP, and TNF-α levels, and negatively correlated with superoxide dismutase activity. The O. formigenes intervention decreased serum and vascular oxalate levels, while did not improve vascular calcification significantly. In addition, systemic inflammation and oxidative stress were also improved in the O. formigenes group. In vitro, high concentrations of oxalate dose-dependently increased oxidative stress and inflammatory factor expression in HAECs, but not in HASMCs. CONCLUSIONS: Our results indicated that hyperoxalemia led to the systemic inflammation and the activation of oxidative stress. The reduction in oxalate levels by O. formigenes might be a promising treatment for the prevention of oxalate deposition in calcified areas of patients with ESRD.
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Authors | Ke Sun, Xiaojing Tang, Shuwei Song, Yuan Gao, Hongjing Yu, Ningyun Sun, Bin Wen, Changlin Mei |
Journal | Kidney & blood pressure research
(Kidney Blood Press Res)
Vol. 46
Issue 3
Pg. 377-386
( 2021)
ISSN: 1423-0143 [Electronic] Switzerland |
PMID | 34044409
(Publication Type: Journal Article)
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Copyright | © 2021 The Author(s). Published by S. Karger AG, Basel. |
Chemical References |
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Topics |
- Animals
- Atherosclerosis
(metabolism, pathology)
- Cell Line
- Disease Models, Animal
- Endothelial Cells
(metabolism, pathology)
- Humans
- Male
- Mice
- Oxalates
(metabolism)
- Oxidative Stress
- Renal Insufficiency, Chronic
(metabolism, pathology)
- Uremia
(metabolism, pathology)
- Vascular Calcification
(metabolism, pathology)
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