CASE PRESENTATION: A 75-year-old Japanese man, whose wife reported that his memory was impaired, also suffered from suspected
aphasia. He was pathologically diagnosed with
Alzheimer's disease using 11C-Pittsburgh compound-B positron emission tomography and
18F-THK5351 positron emission tomography. Based on clinical observation and the results of the Japanese standard language test of
aphasia, he was also diagnosed with nonfluent/agrammatic variant
primary progressive aphasia. During the subsequent 2 years, his
cognitive impairment,
aphasia, and behavioral and psychological symptoms of
dementia progressed. Furthermore, progression of pathologic
amyloid-β and
tau protein deposition was revealed through 11C-Pittsburgh compound-B positron emission tomography and
18F-THK5351 positron emission tomography. Although the results of [123I] iodoamphetamine single-photon emission computed tomography suggested
corticobasal degeneration, this was not observed on the [123I]
FP-CIT single-photon emission computed tomography (SPECT) (DaTscan). A previous study had reported that
Alzheimer's disease with a nonfluent/agrammatic variant
primary progressive aphasia was accompanied by
corticobasal degeneration; however, this was not true in our case.
CONCLUSIONS: