Fibrinogen Dysregulation is a Prominent Process in Fatal Conditions of COVID-19 Infection; a Proteomic Analysis.

Abstract

INTRODUCTION:

Molecular pathophysiology of COVID-19 is not completely known. Expression changes in patients' plasma proteins have revealed new information about the disease. Introducing the key targeted plasma protein in fatal conditions of COVID-19 infection is the aim of this study.

METHODS:

Significant differentially expressed proteins (DEPs) in the plasma of cases with a fatal condition of COVID-19 were extracted from an original article. These proteins were included in a network via STRING database along with 100 first neighbor proteins to determine central nodes of the network for analyzing.

RESULTS:

Queried and added proteins were included in a scale free network. Three hub nodes were identified as critical target proteins. The top queried hub proteins were chains of fibrinogen; Fibrinogen Alpha chain (FGA), Fibrinogen gamma chain (FGG), and Fibrinogen beta chain (FGB), which are related to the coagulation process.

CONCLUSIONS:

It seems that fibrinogen dysregulation has a deep impact on the fatality of COVID-19 infection.

• Authors: Mostafa Rezaei-Tavirani, Mohammad Rostami Nejad, Babak Arjmand, Sina Rezaei Tavirani, Mohammadreza Razzaghi, Vahid Mansouri
• Journal: Archives of academic emergency medicine (Arch Acad Emerg Med) Vol. 9 Issue 1 Pg. e26 ( 2021) ISSN: 2645-4904 [Electronic] Iran
• PMID: 34027421 (Publication Type: Journal Article)