Differentiation of microinfiltration and simple-edema areas in VX2 bone tumors by diffusion kurtosis imaging in animal experiments: a preliminary study.

Abstract

BACKGROUND:

Dual-energy computed tomography, diffusion-weighted imaging (DWI), and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can be used to distinguish microinvasion areas of malignant bone tumors. However, reports of diffusion kurtosis imaging (DKI) to determine the extent of intramedullary infiltration are relatively rare.

PURPOSE:

To assess the application value of MR-DKI in differentiating areas of microinfiltration and simple edema in rabbit bone VX2 tumor models.

MATERIAL AND METHODS:

Conventional MRI and DKI were performed on 25 successfully constructed rabbit VX2 bone tumor models. We acquired a midline sagittal section of the tumor for hematoxylin and eosin staining. Using pathological findings as the gold standard and combining them with MRI data, strict point-to-point control was performed to delineate regions of interest (ROIs) in the microinfiltration and simple-edema areas of bone tumors for quantitative measurement of mean diffusivity (MD) and mean kurtosis (MK). MD and MK values between microinfiltration and simple-edema areas were compared using an independent sample t-test, and the diagnostic values were evaluated by receiver operating characteristic (ROC) curve analysis.

RESULTS:

In comparison with the simple-edema area, the micro-infiltration area demonstrated significantly smaller MD values and larger MK values (P < 0.05), and MD showed a better area under the curve (AUC) than MK (AUC = 0.884 vs. AUC = 0.690) for distinguishing the microinfiltration area from the simple-edema area. The optimal cutoff MD value was 1108.5 mm2/s with a sensitivity of 84% and specificity of 84%.

CONCLUSION:

DKI can distinguish the microinfiltration and simple-edema areas of malignant bone tumors in animal experiments.

• Authors: Fang Yajun, Tang Limin, Zhou Ruizhi, Xu Qi, Chen Haisong
• Journal: Acta radiologica (Stockholm, Sweden : 1987) (Acta Radiol) Vol. 63 Issue 6 Pg. 794-801 (Jun 2022) ISSN: 1600-0455 [Electronic] England
• PMID: 34000825 (Publication Type: Journal Article)

Topics

• Animals
• Bone Neoplasms (diagnostic imaging)
• Diffusion Magnetic Resonance Imaging (methods)
• Diffusion Tensor Imaging (methods)
• Edema
• Humans
• Rabbits
• Sensitivity and Specificity