Abstract | BACKGROUND:
Acanthosis nigricans (AN) is a common dermatological issue with several therapeutic modalities to treat. Despite retinoid is the first drug of choice in the treatment, the fractional-ablative carbon dioxide ( CO2 ) laser has revealed as a promising procedure for the management of neck-AN, outstanding to its ability for superficial ablation of the skin surface, with trans-epidermal melanin elimination. OBJECTIVES: To decide whether fractional-ablative CO2 laser or retinoic acid (5%) peel is the more effective and safe choice for AN treatment. METHODS: In this study, twenty Egyptian cases with neck-AN were enrolled, where each case was exposed to four sessions with 2 weeks apart of both fractional CO2 laser on the right half of the neck and retinoic acid peel on the left half of the neck. Cases were assessed by a scoring system: Acanthosis Nigricans Area and Severity Index (ANASI) score, two blinded dermatologists, and dermoscopically before and one month after treatment. RESULTS: We found a highly statistically significant improvement among both treated groups regarding (ANASI) score and dermatologist's assessments. Bedside, the degree of sulci cutis, cristae cutis, brown-to-dark brown dots, and milia-like cysts, dermoscopic sign improvement was evident in both treated groups. However, fractional CO2 laser shows the superior result to retinoic acid peel in the treatment. CONCLUSION:
|
Authors | Ayat A Abu Oun, Naglaa A Ahmed, Hala S A Hafiz |
Journal | Journal of cosmetic dermatology
(J Cosmet Dermatol)
Vol. 21
Issue 3
Pg. 1023-1030
(Mar 2022)
ISSN: 1473-2165 [Electronic] England |
PMID | 33998772
(Publication Type: Journal Article)
|
Copyright | © 2021 Wiley Periodicals LLC. |
Chemical References |
|
Topics |
- Acanthosis Nigricans
(drug therapy)
- Carbon Dioxide
- Chemexfoliation
- Humans
- Lasers, Gas
(adverse effects)
- Treatment Outcome
- Tretinoin
(therapeutic use)
|