Myelin oligodendrocyte glycoprotein (MOG) antibody disease has been recognised as a distinct
demyelinating disorder.
Optic neuritis has been reported as the most common presentation and manifestation of this spectrum disorder. This is a case series of three MOG
optic neuritis patients. Patients involved are female with disease onset ranging between 7- and 37-year-old. Most of these patients experienced symptoms of profound reduced visual acuity with
eye pain. All three patients had optic disc swelling upon first presentation and they experienced at least one episode of bilateral simultaneous
optic neuritis. Only one patient had demonstrable optic nerve enhancement on magnetic resonance imaging (MRI). Disease was confirmed through positive MOG antibody. Patients typically responded well to intravenous
methylprednisolone (IVMP) during acute attack of
optic neuritis. However, one patient had suboptimal response to IVMP after multiple relapses. We noted multiple relapses of
optic neuritis are common in MOG patients. MOG
optic neuritis is a devastating, but treatable condition. Aggressive treatment during acute
optic neuritis attack and
relapse prevention may favour a good visual prognosis in MOG antibody disease.