Congenital Hypogonadotropic Hypogonadism with Early-Onset Coronary Artery Disease.

Abstract

The patient with congenital hypogonadotropic hypogonadism (HH) shows low serum levels of androgen, which is a group of sex hormones including testosterone, caused by the decreased gonadotropin release in the hypothalamus. Recent reports showed androgens exert protective effects against insulin resistance or atherosclerotic diseases, such as diabetes mellitus or coronary artery disease. However, whether the juvenile hypogonadism affects the diabetes or cardiovascular disease is unclear. We report a case of a middle-aged man with congenital HH who had severe coronary artery disease complicated with metabolic disorders. J. Med. Invest. 68 : 189-191, February, 2021.

• Authors: Akira Takashima, Shusuke Yagi, Koji Yamaguchi, Kiyoe Kurahashi, Yuko Kojima, Robert Zheng, Takayuki Ise, Kenya Kusunose, Sumiko Yoshida, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Ken-Ichi Aihara, Masashi Akaike, Masataka Sata
• Journal: The journal of medical investigation : JMI (J Med Invest) Vol. 68 Issue 1.2 Pg. 189-191 ( 2021) ISSN: 1349-6867 [Electronic] Japan
• PMID: 33994469 (Publication Type: Case Reports, Journal Article)

Chemical References

• Testosterone

Topics

• Coronary Artery Disease (complications)
• Humans
• Hypogonadism (complications)
• Insulin Resistance
• Male
• Middle Aged
• Testosterone