Traditional Chinese medicine prescription Guizhi Fuling Pills in the treatment of endometriosis.

Abstract

Endometriosis (EMs) is recorded as Zheng Jia in traditional Chinese medicine (TCM) books. Guizhi Fuling Pills (GFPs), a classic prescription for promoting blood circulation and removing blood stasis, is widely used for women's blood stasis diseases represented by Zheng Jia. At present, it has been applied to treat EMs in clinical settings. In this review, we systematically summarized the active ingredients and pharmacological mechanism of five Chinese herbs contained in GFPs and clinical applications of GFPs. The potential pathways of GFPs in the treatment of EMs were explored through network pharmacology. The current researches results indicate that the mechanisms of GFPs in the treatment of EMs mainly include acesodyne, anti-inflammation and improvement of hemodynamics. The main active compounds that are responsible for pharmacological effects in five Chinese herbs are paeonol, pachymic acid, cinnamaldehyde, amygdaloside and Paeoniflorin. This review can lay the foundation and identify the research direction for the development of GFPs as a new drug therapy for the treatment of EMs.

• Authors: Xin Wang, Yaxin Shi, Li Xu, Zilu Wang, Yanfei Wang, Wei Shi, Ke Ma
• Journal: International journal of medical sciences (Int J Med Sci) Vol. 18 Issue 11 Pg. 2401-2408 ( 2021) ISSN: 1449-1907 [Electronic] Australia
• PMID: 33967618 (Publication Type: Journal Article, Review)
• Copyright: © The author(s).

Chemical References

• Drugs, Chinese Herbal
• guizhi-fuling

Topics

• Drugs, Chinese Herbal (chemistry, pharmacology, therapeutic use)
• Endometriosis (drug therapy)
• Female
• Humans
• Medicine, Chinese Traditional (methods)
• Protein Interaction Mapping
• Protein Interaction Maps (drug effects)