Clinicopathological Features of Growth Hormone-producing Pituitary Adenomas and Correlation With Preoperative Laboratory Findings.

Abstract

BACKGROUND/AIM:

The histopathological variability of each type of pituitary adenoma (PA) that causes growth hormone (GH) excess influences the phenotype, radiological characteristics and therapy response of acromegaly patients. We correlated the immunohistochemical (IHC) features of GH-secreting PAs with their clinical, laboratory and imaging data.

PATIENTS AND METHODS:

We included 32 patients with documented acromegaly; tumour specimens were histologically and IHC examined: anterior pituitary hormones, pituitary-specific transcription factor-1 (PIT-1), Ki-67 labelling index were evaluated.

RESULTS:

Macroadenomas represented 93.75%. Post-surgery disease control negatively correlated with the maximum initial tumour diameter (p=0.04). Ki-67 did not predict remission. No correlation was found between GH serum levels and IHC expression (p=0.45). PIT-1 was positive in all specimens, two had a weak expression. Four were considered PIT-1 positive plurihormonal adenomas and several had unusual IHC combinations.

CONCLUSION:

PIT-1 accurately classifies GH-secreting PAs. The IHC classification as well as radiological dimensions and extent influence disease control, probably being the best prognosis factors.

• Authors: Iulia Florentina Burcea, Valeria Nicoleta Năstase, Anca Maria Cîmpean, Amalia Raluca Ceaușu, Ionela Baciu, Cristina Căpățînă, Roxana Dusceac, Simona Găloiu, Dan Niculescu, Șerban Radian, Raluca Trifănescu, Anda Dumitrașcu, Laurențiu Cătălin Cocoșilă, Marius Raica, Cătălina Poiană
• Journal: Anticancer research (Anticancer Res) Vol. 41 Issue 5 Pg. 2669-2680 (May 2021) ISSN: 1791-7530 [Electronic] Greece
• PMID: 33952498 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• Ki-67 Antigen
• Pituitary Hormones, Anterior
• Transcription Factor Pit-1
• Growth Hormone

Topics

• Acromegaly (blood, complications, genetics, pathology)
• Adult
• Aged
• Female
• Gene Expression Regulation, Neoplastic (genetics)
• Growth Hormone (blood)
• Humans
• Ki-67 Antigen (blood)
• Male
• Middle Aged
• Neoplasms, Hormone-Dependent (blood, genetics, pathology)
• Pituitary Hormones, Anterior (blood)
• Pituitary Neoplasms (blood, complications, genetics, pathology)
• Preoperative Period
• Transcription Factor Pit-1 (blood)