Ubrogepant in the Acute Management of Migraine: A Narrative Review.

Abstract

Ubrogepant is a small-molecule calcitonin gene-related peptide (CGRP) receptor antagonist that received Food and Drug Administration (FDA) approval for the acute treatment of migraine with and without aura in adults. The ACHIEVE I and ACHIEVE II Phase III clinical trials showed that ubrogepant was superior to placebo for pain freedom and freedom of the most bothersome migraine-associated symptom at 2 hours after medication intake. The 52-week open label extension of the Phase III trials demonstrated safety of ubrogepant. A real-world study conducted at a tertiary headache center also confirmed the efficacy and safety of ubrogepant. Adverse event rates were higher in the real-world population. Studies are needed to evaluate its long-term efficacy and safety, especially in the setting of co-administration with other CGRP modulating therapies such as the CGRP monoclonal antibodies.

• Authors: Chia-Chun Chiang, Juliana H VanderPluym
• Journal: Journal of pain research (J Pain Res) Vol. 14 Pg. 1185-1192 ( 2021) ISSN: 1178-7090 [Print] New Zealand
• PMID: 33948091 (Publication Type: Journal Article, Review)
• Copyright: © 2021 Chiang and VanderPluym.