Abstract | BACKGROUND: MATERIALS AND METHODS: A comprehensive literature search was performed following PRISMA guidelines. The systematic search was conducted using electronic databases, namely Scopus, Web of Science and PubMed, between October and November 2020 to identify randomized controlled trials (RCT) and, prospective randomized studies (PRS). RESULTS: The analyzed population consists of 376 patients with uterine or cervical cancer, treated with hyaluronic acid, vitamin A, vitamin E, alpha-tocopherol acetate and dienestrol. Intervention with HA along with vitamin A and vitamin E revealed advantage in endpoints such as reduced dyspareunia, vaginal mucosal inflammation, vaginal dryness, bleeding, fibrosis and cellular atypia. Administration of alpha-tocopherol acetate reduced vaginal mucosal inflammation and improved vaginal acanthosis, whereas dienestrol resulted in reduced dyspareunia, vaginal caliber and bleeding. CONCLUSIONS:
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Authors | Adrianna Wierzbicka, Dorota Mańkowska-Wierzbicka, Stanisław Cieślewicz, Marta Stelmach-Mardas, Marcin Mardas |
Journal | International journal of environmental research and public health
(Int J Environ Res Public Health)
Vol. 18
Issue 8
(04 08 2021)
ISSN: 1660-4601 [Electronic] Switzerland |
PMID | 33918070
(Publication Type: Journal Article, Review, Systematic Review)
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Topics |
- Atrophy
- Brachytherapy
(adverse effects)
- Dyspareunia
- Female
- Humans
- Vaginal Diseases
(etiology, prevention & control)
- Vaginitis
(drug therapy, prevention & control)
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