Polysaccharides-modified chitosan as improved and rapid hemostasis foam sponges.

Abstract

Serial hemostatic sponges consisting of polysaccharides-modified chitosan foam sponges were prepared by Schiff base crosslinking reaction between the deacetylated chitosan and oxidized dialdehyde cellulose. Such composite foam sponges were characterized by scanning electron microscopy and Fourier-transform infrared spectroscopy to confirm their morphology and compositions. Then the coagulation process was evaluated in vitro by thrombus elasticity meters. Furthermore, the hemostasis experiments on mouse tail vein and rabbit femoral artery were also performed in vivo. The results strongly indicated that such synergistic cellulose-modified chitosan foam sponges showed comprehensively excellent water-absorbing quality, improved mechanical performance, low hemolysis rates, benign cytotoxicity, good resilience ability after repeated compression, and superior hemostasis capability both in vitro and in vivo. Furthermore, the hemostatic mechanism is via adhering/activating the red blood cell/platelet to form robust blood clots through the endogenous coagulation pathway, which serves as a good candidate for emergency trauma treatment in daily civilian and military hemostasis.

• Authors: Xiaohui Wei, Sheng Ding, Shisheng Liu, Kun Yang, Junjie Cai, Fan Li, Chunlai Wang, Song Lin, Feng Tian
• Journal: Carbohydrate polymers (Carbohydr Polym) Vol. 264 Pg. 118028 (Jul 15 2021) ISSN: 1879-1344 [Electronic] England
• PMID: 33910719 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 Elsevier Ltd. All rights reserved.

Chemical References

• Hemostatics
• Polysaccharides
• Schiff Bases
• Cellulose
• Chitosan
• 2,3-dialdehydocellulose

Topics

• Animals
• Bandages
• Blood Coagulation (drug effects)
• Cell Line
• Cellulose (analogs & derivatives, chemistry)
• Chitosan (chemistry, pharmacology)
• Erythrocytes (metabolism)
• Femoral Artery (injuries, metabolism)
• Hemolysis (drug effects)
• Hemostasis (drug effects)
• Hemostatics (chemistry, pharmacology)
• Male
• Mice
• Microscopy, Electron, Scanning (methods)
• Polysaccharides (chemistry, pharmacology)
• Rabbits
• Schiff Bases (chemistry)
• Spectroscopy, Fourier Transform Infrared (methods)
• Thrombosis (metabolism)