Abstract | OBJECTIVE: METHODS: Totally, 389 patients with GD, 334 patients with HT, 108 T1DM patients with AITD and 115 healthy controls (HC) were recruited in the study. Islet autoantibodies (ZnT8A, GADA and IA-2A) were detected by radioligand binding assay. Thyroid autoantibodies, TPOAb and TGAb were detected by chemiluminescence assay, and TRAb was detected by RIA. RESULTS: The prevalence of ZnT8A, GADA and IA-2A was higher in GD and HT patients than that of HC (ZnT8A: GD 8.48%, HT 10.8% vs HC 1.74%; GADA: GD 7.46%, HT 7.74% vs HC 0.870%; IA-2A: GD 4.88%, HT 3.59% vs HC 0%; All P < 0.05) but lower than that of T1DM subjects with AITD (ZnT8A: 42.6%; IA-2A: 44.4%; GADA: 74.1%; all P < 0.0001). CONCLUSIONS: An increased prevalence of ZnT8A as well as GADA and IA-2A was found in both GD and HT patients, indicating that there is a potential link between thyroid autoimmunity and islet autoimmunity.
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Authors | Yun Cai, Jieni Yan, Yong Gu, Heng Chen, Yang Chen, Xinyu Xu, Mei Zhang, Liping Yu, Xuqin Zheng, Tao Yang |
Journal | Endocrine connections
(Endocr Connect)
Vol. 10
Issue 5
Pg. 534-542
(May 19 2021)
ISSN: 2049-3614 [Print] England |
PMID | 33909592
(Publication Type: Journal Article)
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