Abstract |
Effect of prolong use of orthovanadate nanoparticles (GdVO4/Eu3+ NPs (8 × 25 nm)) on life quality and survival of male Wistar rats on the late stage of ontogenesis (from 23 months to the end of life) has been investigated. Multi-parametric assessment of orthovanadate NPs influences against metformin (Met) which is a well-known calorie restriction mimetic (CR-mimetic) has been completed. The quality of life was assessed by taking into account age-related hallmarks-phenotype and some physiological parameters (condition of the coat, body weight, concentration of thyroxine, rectal temperature) as well as indicators of the pro-oxidant/ antioxidant balance of blood and liver (the content of lipid hydroperoxides; aconitase, glutathione peroxidase, glutathione reductase, glutaredoxin activity, and activity of NADP+- dehydrogenases (DG) ( glucose-6-phosphate DG, malate DG, and isocitrate DG)) in aging animals. Kaplan-Meier curve and Gehan tests with Yates' correction were performed for the survival analysis. It has been found that long-term use of GdVO4/Eu3+ NPs (0.25-0.30 mg/kg/day), as well as Met (100-110 mg/kg/day) with drinking water led to reliable improvement of physiological parameters and normalization of the pro-oxidant/ antioxidant balance in the liver and blood of experimental animals. A significant increase in the survival rate of aging rats was observed; the apparent median survival for control rats was 900 days, while for experimental rats, 1010 and 990 days for GdVO4/Eu3+ NPs and Met, respectively. In general, the data obtained demonstrate the ability of GdVO4/Eu3+ NPs and CR-mimetic-Met to improve the quality of life and increase the survival of an elderly organism.
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Authors | Yuri V Nikitchenko, Vladimir K Klochkov, Nataliya S Kavok, Nina A Karpenko, Irina V Nikitchenko, Svetlana L Yefimova, Anatoly I Bozhkov |
Journal | Biological trace element research
(Biol Trace Elem Res)
Vol. 200
Issue 3
Pg. 1237-1247
(Mar 2022)
ISSN: 1559-0720 [Electronic] United States |
PMID | 33900529
(Publication Type: Journal Article)
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Copyright | © 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. |
Chemical References |
- Antioxidants
- Vanadates
- Metformin
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Topics |
- Aging
- Animals
- Antioxidants
- Male
- Metformin
(pharmacology)
- Nanoparticles
- Quality of Life
- Rats
- Rats, Wistar
- Vanadates
(pharmacology)
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