Paeoniflorin protects against dextran sulfate sodium (DSS)-induced colitis in mice through inhibition of inflammation and eosinophil infiltration.

Abstract

Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) that causes inflammation and ulcers in the digestive tract. The treatment commonly includes anti-inflammatory agents like 5-aminosalicylic acid or corticosteroids or biologics for people with UC who are no longer responding to corticosteroids. The radices of Paeonia lactiflora Pall. or similar plants of the Paeonia genus have been used in Chinese medicine to treat certain diseases that resemble the symptoms of UC. Paeoniflorin, a terpenoid glycoside, is a major active component for the anti-inflammatory and antitumor activity. In this study, we evaluated the therapeutic effect of paeoniflorin (PF) against dextran sulfate sodium (DSS)-induced colitis in mice and found that PF exhibited protective activity against colitis. PF treatment suppressed NF-κB pathway activation, resulting down regulation of pro-inflammatory factor expression. In addition, we detected reduction in eosinophil-related chemokine gene expression and eosinophil infiltration. The treatment also reversed Treg cell population suppression. Although PF treatment did not block COX2 induction, the compound weakly inhibited COX2 activity in an enzymatic assay. Taken together, PF exerts its therapeutic activity against UC through inhibition of inflammation and eosinophil infiltration.

• Authors: Jingjing Li, Suiyuan Ren, Meng Li, Jingai Bi, Guang Yang, Erguang Li
• Journal: International immunopharmacology (Int Immunopharmacol) Vol. 97 Pg. 107667 (Aug 2021) ISSN: 1878-1705 [Electronic] Netherlands
• PMID: 33887576 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 Elsevier B.V. All rights reserved.

Chemical References

• Anti-Inflammatory Agents
• Glucosides
• Monoterpenes
• peoniflorin
• Dextran Sulfate

Topics

• Animals
• Anti-Inflammatory Agents (pharmacology, therapeutic use)
• Colitis, Ulcerative (chemically induced, drug therapy, immunology, pathology)
• Colon (drug effects, immunology, pathology)
• Dextran Sulfate (administration & dosage, toxicity)
• Disease Models, Animal
• Eosinophils (drug effects, immunology)
• Female
• Glucosides (pharmacology, therapeutic use)
• Humans
• Intestinal Mucosa (drug effects, immunology, pathology)
• Mice
• Monoterpenes (pharmacology, therapeutic use)
• Paeonia (chemistry)
• Signal Transduction (drug effects, immunology)