Metabolic effects of 1-week binge drinking and fast food intake during Roskilde Festival in young healthy male adults.

Abstract

AIMS/HYPOTHESIS:

Metabolic effects of intermittent unhealthy lifestyle in young adults are poorly studied. We investigated the gluco-metabolic and hepatic effects of participation in Roskilde Festival (1 week of binge drinking and junk food consumption) in young, healthy males.

METHODS:

Fourteen festival participants (FP) were studied before, during and after 1 week's participation in Roskilde Festival. Fourteen matched controls (CTRL) who did not participate in Roskilde Festival or change their lifestyle in other ways were investigated along a similar timeline.

RESULTS:

The FP group consumed more alcohol compared to their standard living conditions (2.0 ± 3.9 vs 16.3 ± 8.3 units/day, P < 0.001). CTRLs did not change their alcohol consumption. AUC for glucose during OGTT did not change in either group. C-peptide responses increased in the FP group (206 ± 24 vs 236 ± 17 min × nmol/L, P = 0.052) and the Matsuda index of insulin sensitivity decreased (6.2 ± 2.4 vs 4.7 ± 1.4, P = 0.054). AUC for glucagon during oral glucose tolerance test (OGTT) increased in the FP group (1037 ± 90 vs 1562 ± 195 min × pmol/L, P = 0.003) together with fasting fibroblast growth factor 21 (FGF21) (62 ± 30 vs 132 ± 72 pmol/L, P < 0.001), growth differentiation factor 15 (GDF5) (276 ± 78 vs 330 ± 83 pg/mL, P = 0.009) and aspartate aminotransferase (AST) levels (37.6 ± 6.8 vs 42.4 ± 11 U/L, P = 0.043). Four participants (29%) developed ultrasound-detectable steatosis and a mean strain elastography-assessed liver stiffness increased (P = 0.026) in the FP group.

CONCLUSIONS/INTERPRETATION:

Participation in Roskilde Festival did not affect oral glucose tolerance but was associated with a reduction in insulin sensitivity, increases in glucagon, FGF21, GDF15 and AST and lead to increased liver stiffness and, in 29% of the participants, ultrasound-detectable hepatic steatosis.

• Authors: Mia Demant, Malte P Suppli, Signe Foghsgaard, Lise Gether, Magnus F G Grøndahl, Niels B Dalsgaard, Sigrid S Bergmann, Amalie R Lanng, Lærke S Gasbjerg, Martin Thomasen, Jonatan I Bagger, Charlotte Strandberg, Merete J Kønig, Henning Grønbæk, Ulrik Becker, Nicolai J Wewer Albrechtsen, Jens J Holst, Joachim Knop, Matthew P Gillum, Tina Vilsbøll, Filip K Knop
• Journal: European journal of endocrinology (Eur J Endocrinol) Vol. 185 Issue 1 Pg. 23-32 (May 21 2021) ISSN: 1479-683X [Electronic] England
• PMID: 33886497 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• C-Peptide
• FGF21 protein, human
• GDF15 protein, human
• Growth Differentiation Factor 15
• Fibroblast Growth Factors
• C-Reactive Protein
• Glucagon
• Aspartate Aminotransferases

Topics

• Adult
• Aspartate Aminotransferases (metabolism)
• Binge Drinking (metabolism)
• Blood Glucose (metabolism)
• C-Peptide (metabolism)
• C-Reactive Protein (metabolism)
• Denmark
• Diet
• Elasticity Imaging Techniques
• Fast Foods
• Fatty Liver (diagnostic imaging, metabolism)
• Fibroblast Growth Factors (metabolism)
• Glucagon (metabolism)
• Glucose Tolerance Test
• Growth Differentiation Factor 15 (metabolism)
• Holidays
• Humans
• Insulin Resistance
• Liver (diagnostic imaging)
• Male
• Young Adult